Fig. 2: A20 promotes GC metastasis in vivo. | Cell Death Discovery

Fig. 2: A20 promotes GC metastasis in vivo.

From: A20 enhances the migration and metastasis of gastric cancer cells by promoting occludin degradation

Fig. 2: A20 promotes GC metastasis in vivo.The alternative text for this image may have been generated using AI.

A Kaplan–Meier survival analysis showed that A20 knockdown significantly prolonged survival of orthotopic MKN45 tumor-bearing mice (p = 0.029). B A20 knockdown did not significantly affect total stomach weight (p = 0.063) but markedly reduced peritoneal metastatic tumor burden. C IHC staining for cytokeratin 19 (CK19) revealed decreased distant organ metastasis in mice injected with A20 knockdown MKN45 cells compared to parental cells. D The number of metastatic tumor nodules was reduced per mouse following knockdown of A20. Data are presented as mean ± SEM (n = 5). **p < 0.01. E Metastatic tumors in distant organs were detected using IVIS imaging in the MKN45 scramble group (n = 8) and the MKN45 shA20 group (n = 8).

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