Fig. 6: RhoA/ROCK2 signaling is involved in A20-induced migration and occludin degradation in GC cells. | Cell Death Discovery

Fig. 6: RhoA/ROCK2 signaling is involved in A20-induced migration and occludin degradation in GC cells.

From: A20 enhances the migration and metastasis of gastric cancer cells by promoting occludin degradation

Fig. 6: RhoA/ROCK2 signaling is involved in A20-induced migration and occludin degradation in GC cells.The alternative text for this image may have been generated using AI.

A Knockdown of A20 reduced RhoA expression in MKN45 cells. B Increased RhoA expression was detected in AO/WT1 AGS cells. C IF staining showed co-localization of A20 (red) with RhoA (green) in AGS cells. D RhoA knockdown upregulated occludin expression in both AO/WT1 and vector control AGS cells. E Knockdown of RhoA or treatment with the Rho inhibitor Rho i suppressed cell migration in both AO/WT1 and vector control AGS cells. F OTUmut decreased ROCK2 phosphorylation without affecting ERK phosphorylation in AGS cells. Data are presented as mean ± SEM (n = 3 independent experiments). Statistically significant differences are indicated (*p < 0.05, **p < 0.01, ***p < 0.001).

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