Fig. 3: Repopulated microglia of the retina are not derived from Nestin-positive cells. | Cell Discovery

Fig. 3: Repopulated microglia of the retina are not derived from Nestin-positive cells.

From: Dual extra-retinal origins of microglia in the model of retinal microglia repopulation

Fig. 3: Repopulated microglia of the retina are not derived from Nestin-positive cells.The alternative text for this image may have been generated using AI.

a Scheme of tamoxifen triggered fate mapping for Nestin-expressing cells prior to the microglial depletion period. b, c The rationale and hypotheses of tamoxifen inducible fate mapping. d No tdTomato-positive microglia are found in the retina of the treatment protocol (a), in which tamoxifen is administered prior to microglial depletion. e Scheme of tamoxifen triggered fate mapping for Nestin-positive cells in the last 4 days of microglial depletion period. f No tdTomato-positive microglia are found in the retina of the treatment protocol (e), in which tamoxifen is administered during microglial depletion. S: superior; I: inferior; N: nasal; T: temporal; PLX5622: PLX5622 formulated diet; CD: control diet; TAM: tamoxifen. Green: Iba1; red: tdTomato

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