Fig. 5: KU60019, an ATM inhibitor, induces DNA damage and cell apoptosis via inhibiting ATM pathway. | Cell Discovery

Fig. 5: KU60019, an ATM inhibitor, induces DNA damage and cell apoptosis via inhibiting ATM pathway.

From: Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection

Fig. 5: KU60019, an ATM inhibitor, induces DNA damage and cell apoptosis via inhibiting ATM pathway.

a KU60019 inhibits ATM/pATM expressions in naive CD4 T cells. Representative imaging and summary data show western blot analysis for ATM/pATM expressions in naive CD4 T cells treated with 10 μM KU60019 or DMSO for 48 h. b KU60019 inhibits CHK2/pCHK2 expressions in naive CD4 T cells. c KU60019 enhances γH2AX expression in naive CD4 T cells. d KU60019 increases DNA damage foci (γH2AX/53BP1 co-localization) in naive CD4 T cells. e KU60019 increases T-cell apoptosis in naive CD4 T cells. Av, 7AAD, and active caspase-3 expressions are shown in naive CD4 T cells treated with KU60019 vs. DMSO control at 48 h

Back to article page