Fig. 3 | Cell Discovery

Fig. 3

From: VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Fig. 3

VIRMA modulates abundance and lifetime of mRNAs through mediating m6A installation. a,b Validation of selected mRNA targets with upregulated expression (a) and decreased m6A level (b) upon VIRMA depletion in HeLa cell line. P values calculated using one-tailed Student’s t-test between control and VIRMA depletion samples; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are represented as means ± SEM of n = 3. c, d Measurement of lifetimes of selected mRNAs IGFBP5 (c) and NOTCH1 (d). Data are represented as means ± SEM of n = 3

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