Fig. 2: AbTCR-T cells have a less exhausted surface phenotype and a higher percentage of naïve and stem cell memory T cells compared to CAR-T cells. | Cell Discovery

Fig. 2: AbTCR-T cells have a less exhausted surface phenotype and a higher percentage of naïve and stem cell memory T cells compared to CAR-T cells.

From: A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

Fig. 2

a ET190L1-AbTCR T cells (AbTCR) and ET190L1-CAR-T cells (CAR) were cultured and the number of cells determined at the indicated time points. b–e Flow cytometry analysis of ET190L1-AbTCR-T cells and ET190L1-CAR-T cells at day 10 of in vitro expansion prior to antigen stimulation (b) Proportions of CD4/CD8 within receptor+ cells. c Frequency of naïve (CCR7+ CD45RA+), central memory (CM; CCR7+ CD45RA−), effector memory (EM; CCR7- CD45RA-) and effector (E; CCR7- CD45RA+) T cells within CD8+ receptor+ cells. d Frequency of stem cell memory (SCM; CCR7+ CD45RO- CD95+ CD122+) T cells within CD8+ receptor+ cells. e Expression of T cell differentiation markers CD28, CCR7, and granzyme B (GranB). f Expression of T cell exhaustion markers PD-1, LAG-3, and TIM-3. **P < 0.01

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