Fig. 4: Systolic and diastolic dysfunction in Hutchinson-Gilford progeria syndrome (HGPS) minipigs. | Cell Discovery

Fig. 4: Systolic and diastolic dysfunction in Hutchinson-Gilford progeria syndrome (HGPS) minipigs.

From: Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome

Fig. 4

Cardiac magnetic resonance imaging (MRI) and echocardiography analysis of HGPS minipigs (n = 7–8) and wild-type (WT) minipigs (n = 5–6) of a similar age (~4.3–5.5 months) revealed enlarged left atria (LA) and increased left ventricular (LV) filling pressures, as well as systolic and diastolic LV dysfunction in HGPS minipigs. a MRI measurements of LV ejection fraction (LVEF). Representative four chamber long axis views are shown on the left. b Echocardiographic measurements of mitral early wave deceleration time (shown in yellow numbers in the representative images on the left). c Echocardiographic measurements of LA size (shown in yellow numbers in the representative images on the left. See also unaffected systolic and diastolic parameters in HGPS minipigs in Supplementary Fig. S5

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