Table 2 Comparison of SARS-CoV-2 RBD binding to cACE2 or hACE2.
From: Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
SARS-CoV-2 RBD | cACE2 | hACE2 |
|---|---|---|
K417 (4,1/3,1) | E30 (4,1) | D30 (3,1) |
G446 (1/2,1) | Q42 (1) | Q42 (2,1) |
Y449 (12,1/7,2) | E38 (9,1), Q42 (3) | D38 (5,1), Q42 (2,1) |
Y453 (5/3,1) | H34 (5) | H34 (3,1) |
L455 (5/4) | E30 (1), H34 (4) | H34 (4) |
F456 (13/7) | T27 (4), E30 (4), K31 (5) | T27 (5), D30 (1), K31 (1) |
Y473 (1/0) | T27 (1) | |
A475 (0/5,1) | S19 (3,1), Q24 (1), T27 (1) | |
G476 (0/2) | S19 (2) | |
S477 (4,1/0) | Q18 (4,1) | |
F486 (5/11) | T82 (5) | M82 (4), Y83 (7) |
N487 (7,1/11,2) | L24 (3), Y83 (4,1) | Q24 (7,1), Y83 (4,1) |
Y489 (10/7) | T27 (1), F28 (6), K31 (2), Y83 (1) | T27 (2), F28 (4), Y83 (1) |
F490 (0/1) | K31 (1) | |
Q493 (7/6) | H34 (7) | H34 (3), E35 (3) |
G496 (9,1/6,1) | E38 (3), K353 (6,1) | D38 (1), K353 (5,1) |
Q498 (16,2/11,2) | E38 (6,1), Y41(7), Q42 (3, 1) | Y41(5), Q42(5,2), L45(1) |
T500 (18, 3/18) | Y41 (3,1), D355 (12,2), R357 (3) | Y41 (6), N330 (3), D355 (6), R357 (3) |
N501 (6,1/10,1) | Y41 (1), K353 (1), D355 (4,1) | Y41 (5,1), K353 (5) |
G502 (5/8,1) | K353 (1), D355 (4) | K353 (3,1), G354 (5) |
Y505 (15/19) | K353 (9), G354 (2), A386 (1), R393 (3) | E37 (3), K353 (14), G354 (2) |
Total | 143, 11 | 141, 13 |
