Fig. 1: Distribution of HBV DNA–host DNA contacts throughout the Human genome.
From: 3D landscape of Hepatitis B virus interactions with human chromatins
a, b Model of the cell treatment in HBV infection HepG2-NTCP cell system (a) and inducible expression of HBV HepAD38 cell system (b). The HepG2-NTCP cells after HBV infection 6 days and the HepAD38 cells treated with DOX 15 days were used to carry out the 3C-HTGTS experiments. c, d The HBV DNA–host DNA contacts distribution density in different chromosome. HBV infected HepG2-NTCP cells using primer 2 (c) and HepAD38 with DOX cells using primer 2 (d). e UCSC Genome Browser track showing HBV DNA–host DNA contacts throughout the human genome in HepG2-NTCP cell model and in HepAD38 with DOX cell model, respectively (we used vertical viewing range setting for sequencing data display). The red arrows indicate the HBV DNA integration site in HepAD38 cell.
