Fig. 3: Two classes of drugs targeting HS-dependent cargo entry.
From: Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
a A high-throughput drug screen for inhibitors that block the uptake of fluorescently labeled α-Syn fibrils. b A summary of the drugs identified. IC50 was determined by a titration experiment. c A heatmap summary of the endocytosis inhibitory activity for the indicated drugs. All drugs were tested at 10 μM except for Sunitinib and Mitoxantrone (5 μM each). See Supplementary Fig. S2 for details. d Mass spectrometry analysis of drug binding to heparin beads. The indicated drugs were incubated with either control or heparin-conjugated beads. Unbound drugs were quantified by mass spectrometry. n = 2. MTAN, Mitoxantrone.
