Fig. 2: Hematopoietic cell lineages and hierarchically continuous transition model for hematopoiesis. | Cell Discovery

Fig. 2: Hematopoietic cell lineages and hierarchically continuous transition model for hematopoiesis.

From: Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication

Fig. 2: Hematopoietic cell lineages and hierarchically continuous transition model for hematopoiesis.

a Hematopoietic lineages visualized by SPRING, with cells colored by cell type as in Fig. 1e. b, c Expressions of AVP (b) and EMCN (c) are decreasing along hematopoietic lineages. d Heatmap of normalized expression level of early hematopoietic markers along lineages. e Heatmap of transcriptomic dynamics during lymphopoiesis. f–i Coordinated TFs and networks underlying lymphoid lineage. The top 10 coordinated TFs (f); correlation of the coordinated TFs (g); network of coordinated TFs, in which the size of each node represents the magnitude of expression (h); dynamics of TFs expression in regulatory networks along lymphoid lineage (i), in which each node was colored by average expression level. j Hierarchically continuous transition model for hematopoiesis.

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