Fig. 2: Autophagy receptors and selective autophagy.
From: Mendelian neurodegenerative disease genes involved in autophagy
Through the action of autophagy receptors, specific cargoes are recognized and incorporated into autophagosomes for selective degradation180. Autophagy receptors can therefore mediate aggrephagy, mitophagy, pexophagy, ER-phagy, lysophagy, xenophagy, or pexophagy. While this figure aims to provide an overview of the many autophagy receptors involved in different forms of selective autophagy, we have focussed in the text on the most important examples involved in Mendelian neurodegenerative diseases, like P62, ALFY, and OPTN.
