Fig. 6: Inactivation of cGAS in mitosis. | Cell Discovery

Fig. 6: Inactivation of cGAS in mitosis.

From: Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

Fig. 6: Inactivation of cGAS in mitosis.The alternative text for this image may have been generated using AI.

Upon entry to mitosis, cGAS is translocated to chromosomes. The CDK1-cyclin B kinase complex phosphorylates hcGAS at S305 or mcGAS at S291, leading to its inability to synthesize cGAMP in mitotic cells. Upon mitotic exit, PP1 mediates cGAS dephosphorylation which enables its ability to scrutinize the presence of microbial or aberrant-located self-DNA in interphase.

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