Fig. 4: Directionality of light-induced vasodilation is driven by local, but not global NO signaling. | Cell Discovery

Fig. 4: Directionality of light-induced vasodilation is driven by local, but not global NO signaling.

From: The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes

Fig. 4: Directionality of light-induced vasodilation is driven by local, but not global NO signaling.

a In the retina wholemount, vascular diameter changes were monitored at 100 µm long ROIs (boxed) below, above the site of stimulation and at the collateral branch (arrow). b Magnified ROIs under the indicated experimental conditions. c Volumetric analysis of vascular diameter changes at each ROI. Largest vasodilation was observed in the direction toward the feeding branch (ROIs 2 and 1) in response to either flickering spot of light (150 µm, 4 Hz), or focal SNP puff (100 µM), but not during global light stimulation or in the presence of L-NAME (100 µM).

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