Fig. 6: Functional connectivity maps are disrupted in diabetes. | Cell Discovery

Fig. 6: Functional connectivity maps are disrupted in diabetes.

From: The pericyte connectome: spatial precision of neurovascular coupling is driven by selective connectivity maps of pericytes and endothelial cells and is disrupted in diabetes

Fig. 6: Functional connectivity maps are disrupted in diabetes.

a Experimental paradigm of measuring retinal capillary blood flow in mice in vivo. b, c Assessment of retinal capillary blood flow in vivo reveals decline in blood flow in the diabetic mice. d, e Evaluation of cell coupling following pericyte injection ex vivo retinal wholemount at the onset of diabetes (pre-diabetic, 2–3 weeks post STZ treatment) (d) and during established diabetes (3–4 months post STZ treatment) (e). f In diabetic conditions, the GJ-mediated vascular cell coupling is further blocked in the presence of MFA (40 µM). g Effect of NO donor (SNP, 100 µM) on GJ-mediated vascular cell coupling in diabetic conditions (3–4 months post STZ treatment). h Summary of experimental data under each condition (n = 6–9 animals per group).

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