Fig. 1: Overall structure of the LAT1-4F2hc bound with JX-078.
From: Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
a Chemical formulas of the designed LAT1 inhibitors. b The overall cryo-EM map of the LAT1-4F2hc complex bound with JX-078. c The overall structure of the LAT1-4F2hc complex bound with JX-078. The glycosylation moieties are shown as sticks. H, helix. 4F2hc and LAT1 are colored orange and deep blue, respectively.
