Fig. 2: Comprehensive profiling of cytokines and chemokines in COVID-19. | Cell Discovery

Fig. 2: Comprehensive profiling of cytokines and chemokines in COVID-19.

From: Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19

Fig. 2: Comprehensive profiling of cytokines and chemokines in COVID-19.

a Heatmap shows the relative levels of 62 cytokine and chemokines in COVID-19 serum samples. The age, stage (I: 1–10 dpi; II: 10–30 dpi, III: > 30 dpi), and the severity of each case were shown at the bottom. The matrix of raw data is shown in Supplementary Table S3. b Self-organizing map of five clusters of cytokines and chemokines in COVID-19 samples. The samples were divided into six time-coursed (1–5, 6–10, 11–15, 16–20, 21–25, > 26 dpi). The relative levels of cytokines/chemokines were plotted for each patient group (severe/critical and mild/moderate) on the right. Healthy samples were used as controls. Red represents higher levels and blue represents lower levels. c Dynamic changes of the serum levels of GM-CSF, CXCL10, IFNA, TNFSF1A, and TNFSF1B within the first 30 dpi. A total of 51 mild/moderate cases (90 samples) and 24 severe/critical cases (56 samples) were used for plotting.

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