Fig. 3: The effects of INTS3 dimerization and its interaction with INTS6 on INTS3/INTS6 recruitment to DSB sites. | Cell Discovery

Fig. 3: The effects of INTS3 dimerization and its interaction with INTS6 on INTS3/INTS6 recruitment to DSB sites.

From: Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair

Fig. 3

a Cells transfected with SFB-tagged wild-type INTS3 or its mutants were treated with IR (10 Gy) for 6 h or left untreated. Cells were then fixed and processed for immunofluorescence with an anti-Flag antibody. b The quantification of foci-positive cells was performed by counting a total of 300 cells per sample. c Cells transfected with SFB-tagged wild-type INTS6 or the F858A/K859A mutant were fixed and processed for immunofluorescence with anti-Flag antibody.

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