Table 2 Adverse events (AE) in treated patients.

From: Chimeric antigen receptor T cells self-neutralizing IL6 storm in patients with hematologic malignancy

Patient#	1	2	3	5	6	7	8	9	10	11	12	13	14	15	16	17	18	Sum (%)
General disorders
Pyrexia (≥38 °C)	√		√	√	√	√	√	√	√	√	√	√	√	√	√	√	√	89
Malaise/fatigue	√									√								11
Myalgias																		0
Arthralgias																		0
Edema																	√	6
Headache	√									√								11
Dizziness																		0
Rigor																		0
Laboratory tests
Increased CRP(>8 mg/L)	√		√	√	√		√	√	√	√	√	√	√	√	√	√	√	89
Increased SF (Female >150 ng/mL, Male >200 ng/mL)	√	√	√	√	√		√	√	√	√	√		√	√	√	√	√	89
Cardiovascular system
Hypotension
No vasopressor			√			√				√		√	√					28
Vasopressor														√	√	√	√	28
Arrhythmia
Tachycardia	√		√				√		√			√	√	√			√	44
Bradycardia					√					√								11
Pemature beat														√				6
QT prolongation, ST-T changes																	√	6
Decreased LVEF																	√	6
Pericardial effusion										√			√		√		√	22
Elevated troponin																		0
Respiratory system
Dyspnea					√									√	√		√	22
Hypoxemia												√			√		√	17
Ventilator support																		0
Pleural effusion								√		√					√		√	22
Renal system
Increased creatinine	√																	6
Gastrointestinal system
Nausea/vomitting									√	√			√					17
Diarrhea				√				√	√				√				√	22
Abdominal pain								√										6
Edema of the pancreas or gallbladder																	√	6
Elevated liver enzymes
Increased alanine aminotransferase									0	2						1	0	11
Increased aspartate aminotransferase									2	4						3	3	22
ALP							3	1			1		1	1	0	1	2	33
Increased total bilirubin											2							6
Hematologic toxicity
Neutropenia
Mild (<1500/µL)		√	√	√		√												22
Severe (<500/µL)	√				√		√	√	√	√	√	√	√	√	√	√		67
Thrombocytiopenia
Mild (<150 × 10³/µL)		√		√		√			√					√				28
Severe (<50 × 10³/µL)	√				√		√	√		√	√	√	√		√	√	√	61
Anemia
Mild to moderate anemia(≥60 g/L)	√			√	√	√		√	√	√	√					√		50
Severe anemia (<60 g/L)							√						√	√	√		√	28
Coagulation
Elevated D-dimer > 0.55							√	√	√	√	√	√	√	√	√	√	√	61
Hypofibrinogenemia ± bleeding <1.7										√					√		√	17
Prolonged PT								√	√	√							√	22
Prolonged APTT							√	√	√	√							√	22
Neurologic events
Delirium	√																	6
Convulsion																		0
Anxiety																		0
Somnolence																		0
Tremor	√																	6
Disturbance in attention																		0
Speech disorder																		0
Abnormal thinking																		0
Infections
									√	√		√			√		√	28

Certain AE was graded according to NCI CTCAE.

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Table 2 Adverse events (AE) in treated patients.

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