Fig. 3: Landscape of transcriptome in human blastoids on day 6.
From: Generation of human blastocyst-like structures from pluripotent stem cells
a A UMAP plot 10,933 cells from human blastoids showing the cells in blastoids were divided into 4 major clusters on day 6. EPI/ICM, PE, TE, and IM (intermediate) subgroups were determined according to the lineage-specific markers. The cells in IM subgroups express all three lineages markers or some uncertain genes. b Heat map of lineage signature genes expression on day 6. c UMAP projection of integrated datasets showing EPI-, PE-, and TE-like cells (and IM clusters) together with EPI, PE, and TE cells of blastocysts from a previous published study7. d Dot plot indicating the markers of EPI, PE, and TE lineage markers. e Overlapping genes expression between a previous study7 and this study was performed by heat map and GO term analysis.
