Fig. 7: OX40L context-dependency depends mainly on the DC type.

a Euclidean distance between presence and absence of rhOX40L for each Th context, calculated from the 17 PCs of the PCA of the raw data (all cytokines). Thirteen independent donors were used in the analysis. b Euclidean distance between presence (isotype) and absence (OX40L-blocking antibody) of OX40L on DCs for each cDC2 and MoDC context based on a PCA of the 17 Th-cytokines measured (17 PCs). Nine independent donors were used in the analysis. c, d For each of the 17 output Th-cytokines measured in DC–T cocultures, group-lasso coefficients as a function of the penalization parameter (lambda) are represented. c Cytokines for which OX40L context-dependency was predominantly due to the DC type. d Cytokines for which OX40L context-dependency was predominantly due to the DC contexts.