Fig. 2: Cross-species metabolomic features underlying differential regenerative capacities.
From: Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor
a Pie plot showing the percentage of super-pathway for identified metabolites in AB, dASCs, NHP tissues and hMSCs. b PLS-DA analysis of metabolomic data generated in AB, dASCs, NHP tissues and hMSCs. c Bar plot showing the count of DPMPs identified in AB at DPA 11, dASCs, young NHP tissues, and young hMSCs. The percentages of DPMPs in each super-pathway were shown on the top of each bar graph. d The hierarchical clustering dendrogram showing the similarity of the metabolic profile changes in AB at DPA 11, dASCs, young NHP tissues, and young hMSCs. e Heatmap showing the differential abundance (DA) for identified metabolites in each super-pathway in AB at DPA 11, dASCs, young NHP tissues, and young hMSCs. The color key from blue to amaranth indicates DA score from low to high for each super-pathway. f Heatmap showing the differential abundance for identified metabolites in each sub-pathway in AB at DPA 11, dASCs, young NHP tissues, and young hMSCs. Sub-pathways increased in at least seven tissues/cells with higher regenerative capacity were highlighted. The color key from blue to amaranth indicates DA score from low to high for each sub-pathway. g Network diagram showing the representative sub-pathways and relative abundance for DPMPs in each sub-pathway. The color of the edge from grey to amaranth indicates log2(fold change) from low to high. The node sizes are positively correlated to the edge counts for each node.
