Fig. 6: Cryo-EM structure of 2G1 and the complex with WA1/2020S protein. | Cell Discovery

Fig. 6: Cryo-EM structure of 2G1 and the complex with WA1/2020S protein.

From: Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD

Fig. 6: Cryo-EM structure of 2G1 and the complex with WA1/2020S protein.The alternative text for this image may have been generated using AI.

a The domain-colored cryo-EM map of SARS-CoV-2S ectodomain trimer and 2G1 Fab fragments complex is shown, viewed along two perpendicular orientations. The heavy and light chains of 2G1 are colored blue and cyan, respectively. The three protomers of trimeric S protein are colored gray, orange and pink. b–e The binding interface between 2G1 and RBD and adjacent RBD’. RBD and 2G1 interact with each other mainly through hydrophobic interactions (c, d). 2G1 heavy chains (CDRH3 and CDRH1) lie above the adjacent RBD’ (e). Residues are numbered using the Kabat convention.

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