Fig. 2: Overall architecture of the human NALCN channelosome. | Cell Discovery

Fig. 2: Overall architecture of the human NALCN channelosome.

From: Architecture of the human NALCN channelosome

Fig. 2

a Overall structure of the NALCN channelosome shown in three views. NALCN, FAM155A, UNC79, UNC80, and CaM are colored yellow, wheat, pink, cyan, and gray, respectively. The II–III linker of NALCN that interacts with the UNC79–UNC80 assembly is highlighted in red. The color scheme is applied in all figures. b UNC79 and UNC80 adopt an S-shape super-helical structure. The structures are rainbow colored with the N- and C-terminus in blue and red, respectively. c Overall structures of UNC79 and UNC80 predicted by AlphaFold2. The predicted structures form super-helical architecture consisting of HEAT and armadillo repeats. The overall shape is different from the experimental structure as shown in b. d Structure of RyR1 contains a huge super-helical scaffold in the cytoplasmic side (PDB: 3J8H). Only two diagonal protomers of the homo-tetrameric RyR1 are shown for visual clarity.

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