Fig. 3: Architecture of the UNC79–UNC80 assembly. | Cell Discovery

Fig. 3: Architecture of the UNC79–UNC80 assembly.

From: Architecture of the human NALCN channelosome

Fig. 3: Architecture of the UNC79–UNC80 assembly.The alternative text for this image may have been generated using AI.

a Overall structure of the UNC79–UNC80 assembly shown in cartoon. Three interaction interfaces between UNC79 and UNC80 are labeled. b–d Close-up views of the interaction interfaces between UNC79 and UNC80: the C-interface (b), the M-interface (c), and the N-interface (d). The numbers of the UNC79 and UNC80 HA repeats that form the corresponding interfaces are labeled. The side chains of the residues on the interfaces that are mutated and tested by electrophysiological experiments are labeled in color. e Representative current traces recorded from HEK293T cells expressing the WT NALCN channelosome and the constructs with indicated mutations or deletions on the interfaces between UNC79 and UNC80.

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