Fig. 4: Interaction between NALCN II–III linker and the UNC79–UNC80 assembly. | Cell Discovery

Fig. 4: Interaction between NALCN II–III linker and the UNC79–UNC80 assembly.

From: Architecture of the human NALCN channelosome

Fig. 4: Interaction between NALCN II–III linker and the UNC79–UNC80 assembly.The alternative text for this image may have been generated using AI.

a Interaction interface between the II–III linker of NALCN and the UNC79–UNC80 assembly. Flexible regions that are invisible and unmodelled in the structure are indicated by dashed lines. b–d Close-up views of the interfaces between II–III linker of NALCN and the UNC79–UNC80 assembly. Key residues that are involved in interface interactions are shown as sticks. The residues that are mutated and tested by electrophysiological experiments are labeled in color. e Representative current traces from HEK293T cells expressing the WT NALCN channelosome and the constructs with indicated mutations on the interfaces between the II–III linker of NALCN and the UNC79–UNC80 assembly.

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