Fig. 4: Heterogeneous transcriptional changes in keratoconus corneal epithelium. | Cell Discovery

Fig. 4: Heterogeneous transcriptional changes in keratoconus corneal epithelium.

From: Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis

Fig. 4

a UMAP plot of corneal epithelial cells colored by annotated cell types. b Dot plot showing expression patterns of representative markers for each cell type. c Gene scoring analysis using keratinocyte differentiation-related genes. ****P < 0.0001 (two-sided Wilcoxon rank-sum test). d Expression profiling for cornification-related genes across cell subtypes and groups. e, f Expression level of KRT80 (e) and SPRR1B (f) in Ctrl and KC superficial cells (left panel), and immunohistochemical analysis confirmed their elevated expression in KC samples (right panel). ****P < 0.0001 (two-sided Wilcoxon rank-sum test).

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