Fig. 1: Identification of DNA 6mA in human normal brain tissues and glioblastomas. | Cell Discovery

Fig. 1: Identification of DNA 6mA in human normal brain tissues and glioblastomas.

From: Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

Fig. 1

a–c UHPLC-MS/MS chromatograms and quantification of DNA dC and 6mA in normal brain (NB) tissues (a), Glioblastoma (GBM) (b), and Glioblastoma Stem Cells (GSCs) and glial cell line (SVG p12) (c). d UHPLC-MS/MS chromatograms of DNA 6mA in the genome of control brain tissues (NB-2#, ~22 6mA per 108 dC) spiked with or without 6mA standard (~13 6mA per 108 dC) and in the genome of GBM-4# (~1.2 6mA per 108 dC)) spiked with or without 6mA standard (~1.2 6mA per 108 dC). Blank: ultrapure water underwent the purification and digestion as same as real samples.

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