Fig. 2: GW01 binds to an RBD epitope distinct from that of REGN10989 and overlaps with the ACE2-binding site. | Cell Discovery

Fig. 2: GW01 binds to an RBD epitope distinct from that of REGN10989 and overlaps with the ACE2-binding site.

From: Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Fig. 2: GW01 binds to an RBD epitope distinct from that of REGN10989 and overlaps with the ACE2-binding site.

a Binding of GW01 to SARS-CoV-2 RBD (left) and SARS-CoV RBD (right) in competition with S309 and REGN10989 as measured by bilayer interferometry experiments. S309 was used as a control. b Binding of ACE2 to SARS-CoV-2 RBD (left) and SARS-CoV RBD (right) in competition with GW01 (red), S309 (blue), REGN10989 (green), control IgG1, and ACE2.

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