Fig. 1: Transcriptomics analysis of MASCp6-infected aged mouse lungs.
From: Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models
a Overview of the RNA-seq data. Dot plot shows 1066 significantly differentially expressed (P < 0.05 and |log2FC| > 1) genes with 298 downregulated and 768 upregulated in the infected group. FC, fold change. b GO analysis of significantly upregulated genes. Rich factor represents the ratio of significantly differentially expressed genes to the total genes belonging to the GO term. c Heatmap and bar plot show relative expression levels of significantly differentially expressed genes of chemokine, interleukin, and their receptors. d Network of the genes belonging to significantly-enriched immunity-related KEGG terms of significantly upregulated genes. e Heatmap and bar plot show relative expression levels of CD200 and its receptor genes. f Immunostaining results with SARS-CoV-2 nucleocapsid (green) and macrophage marker (CD68, red) antibodies of lung sections from MASCp6-infected and control aged mice. Scale bars, 200 μm.
