Fig. 2: Identification of tumor-specific regulatory elements.
From: Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma
a Heatmap of the Z-score normalized accessibilities of 22,682 scATAC-seq differential peaks for each cell type. b Pie plot of genomic annotations for scATAC-seq differential peaks. c Gene ontology term enrichment analysis for distal (intergenic region) and proximal (promoter and gene body) upregulated DARs in tumor cells. The Benjamini-Hochberg adjusted P values are shown on the right side of the plots. d Heatmap representation of chromVAR bias-corrected deviation scores for the differential TF motifs of each cell type. The top TF motifs of each cell type are indicated on both sides of the plot. e Heatmap of the log2(FC) values for tumor-specific TFs identified by our filtering strategy. The right bar plot shows the Bonferroni-adjusted P values. f Kaplan–Meier overall survival curves of TCGA-KIRC patients grouped by the average expression of tumor-specific TFs (with the median value as the threshold). HR hazard ratio.
