Fig. 7: Schematic model for IRS-1-mediated insulin/IGF signalosomes.
From: Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes
We found that the C-terminus of IRS-1 undergoes phase separation through mediating self-association. Insulin/IGF signaling leads to tyrosine phosphorylation of IRS-1 which promotes the formation of IRS-1 droplets and the recruitment of downstream effectors to form insulin/IGF signalosomes.
