Fig. 3: Overall cryo-EM structures of the S-antibody complexes. | Cell Discovery

Fig. 3: Overall cryo-EM structures of the S-antibody complexes.

From: Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

Fig. 3: Overall cryo-EM structures of the S-antibody complexes.

a Overall structure of SARS-CoV-2 S in complex with F61 Fab. The tilt angle of RBD is defined by the angle between the long axis of RBD (red line) and its projection on the horizontal plane (black ellipse). Angle between them is indicated. SARS-CoV-2 RBD is colored in cyan, other domains in gray, heavy chain of F61 in magenta and light chain of F61 in violet. Related to Supplementary Fig. S2. b Overall structure of SARS-CoV-2 S in complex with D2 Fab. The tilt angle of RBD is defined by the angle between the long axis of RBD (red line) and its projection on the horizontal plane (black ellipse). Angle between them is indicated. SARS-CoV-2 RBD is colored in cyan, other domains in gray, heavy chain of D2 in orange and light chain of D2 in light orange. Related to Supplementary Fig. S3. c Overall structures of SARS-CoV-2 Omicron S in complex with F61 Fab and D2 Fab. Color schemes are the same as a and b. Related to Supplementary Fig. S4. d Structural superposition of RBD-fab and RBD-ACE2 (PDB ID: 6M0J) structures and the footprints of F61, D2 and ACE2 on the RBD, and structure of Omicron-RBD-F61-D2 with footprints of F61 and D2 on the RBD. ACE2 is colored in blue. The footprints of F61, D2 and ACE2 are represented as magenta, orange and blue, respectively. Other color schemes are the same as a and b.

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