Fig. 2: CAPTURE barcoding demonstrates the evolution of PLX-resistant subclones. | Cell Discovery

Fig. 2: CAPTURE barcoding demonstrates the evolution of PLX-resistant subclones.

From: Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

Fig. 2

a Schematic outline of the experimental design. b Heatmap of enriched barcodes (GFOLD log2 fold change > 4) from all replicates compared with vehicle control group. c Cumulative plot of barcode percentages. The shift of the PLX-treated groups represents the enrichment in a subset of barcodes. d Percentage of enriched barcodes in each replicate that were also found in other replicates. e Model demonstrating both selection of preexisting resistance cells and late-emerging resistance cells from drug-tolerant persister cells fuel BRAFi resistance in BRAFV600E melanoma.

Back to article page