Fig. 2: Binding and neutralization of the Omicron variant by bispecific antibodies. | Cell Discovery

Fig. 2: Binding and neutralization of the Omicron variant by bispecific antibodies.

From: Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Fig. 2

a Schematic diagrams showing the structures of bispecific antibodies. b SDS-PAGE and cross-linking SDS-PAGE gels showing the sizes of the representative bispecific antibodies and their parental antibodies. c Binding specificities of the bispecific antibodies to the SARS-CoV-2 RBD-His, Omicron trimer-His, or RBD-His protein. d Binding affinities of the bispecific antibodies to the SARS-CoV-2 RBD-His, Omicron trimer-His, or RBD-His protein were measured by BLI experiments. ND represents not determined. e Neutralization by bispecific antibodies against the SARS-CoV-2 VOCs, including Omicron, BA.2, and sarbecoviruses. f Neutralization of bispecific antibodies against authentic BA.1.1 virus.

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