Fig. 3: Acute B cell activation following by the booster vaccination. | Cell Discovery

Fig. 3: Acute B cell activation following by the booster vaccination.

From: Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

Fig. 3: Acute B cell activation following by the booster vaccination.The alternative text for this image may have been generated using AI.

a UMAP representation of B cells derived from PBMCs. Clusters are denoted by color and labeled with inferred cell types. b Dot plot of average expression and percentage of expressed cells of selected canonical markers in each labeled B cell subtype. c BCR clone differences across time points in each B cell subtype at D0, D3, and D14. d The relative percentage of each isotype in each B cell subtype at D0, D3, and D14. e Dot plot shows the cell cycle score and average expression of cell cycle markers, TOP2A, MCM6 and MKI67, in plasma cells. Dot size depicts the percentage of the indicated gene-expressing cells. f The enriched GO-BP terms of upregulated genes in plasma cells in PrSV group at D3 (left) or D14 (right) post-vaccination. P value was derived by Benjamini & Hochberg test.

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