Fig. 4: Clonal expansion and persistence of B cells. | Cell Discovery

Fig. 4: Clonal expansion and persistence of B cells.

From: Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

Fig. 4: Clonal expansion and persistence of B cells.The alternative text for this image may have been generated using AI.

a Pie plot shows that 11/134 expanded BCR clones detected in D3/D14 plasma cells were derived from naïve B cell, named de novo induced clones, and 17/134 expanded BCR clones detected in D3/D14 plasma cells were derived from memory B cell, named recalled clones. b Boxplot shows the BCR mutation frequency of de novo induced clones and recalled clones. c Average proportions of BCR isotypes between de novo induced clones and recalled clones. d Pie plot shows that 380/1293 expanded BCR clones detected in D3/D14 memory B cells could be detected in D90/D180 memory B cells, named persistent clones. e Average proportions of isotypes of persistent clones compared with BCR clones detected at D90/D180. f Boxplot shows the BCR mutation frequency of persistent clones compared with BCR clones detected at D90/D180. g RidgePlot shows the accumulation of memory cells against booster vaccination.

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