Fig. 4: Cryo-EM of Omicron Spike Trimer with BA7208-Fab. | Cell Discovery

Fig. 4: Cryo-EM of Omicron Spike Trimer with BA7208-Fab.

From: Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5

Fig. 4

a The complex of three BA7208-Fabs (green) with Omicron Spike Trimer (dodger blue, plum, and rosy brown). b The complex of BA7208-Fab (light green, Fab light chain; dark green, Fab heavy chain) with Omicron Spike-RBD in the down conformation (plum). c The complex of BA7208-Fab with Omicron Spike-RBD in the up conformation (dodger blue). d Zoomed-in views of 7208-Fab binding site on Omicron RBD. Side chain of residues that form the hydrogen bonds, salt bridge, and one cation-π interaction are displayed.

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