Fig. 2: Structural analysis of MTA1–MTA9 in the MTA1 complex.
From: Structural insights into DNA N6-adenine methylation by the MTA1 complex
a Overall structure of MTA1–MTA9 in the MTA1 complex. MTA1, magenta; MTA9, green; MTA1 interface loop 1, blue; MTA9 interface loop 2, red. The bound SAM is illustrated as a yellow ball-and-stick surrounded by a dashed ellipse. The DPPW motif and the eroded NALW motif are shown as orange sticks. b Schematic representation of the interactions between MTA1 and SAM. Residues are shown as magenta sticks. SAM is shown as yellow sticks. Hydrogen bonds are shown as black dashed lines. c Superposition of the core MTase domains of MTA1–MTA9 (magenta and green) and METTL3–METTL14 (gray). The bound SAM in MTA1 and METTL3 are shown as yellow and gray balls-and-sticks, respectively. The DPPW motifs in MTA1 and METTL3 are shown as orange and gray sticks, respectively. d Superposition of the SAM molecules and the SAM interacting residues in MTA1 and METTL3, with the same color scheme as c. Hydrogen bonds in MTA1 and METTL3 are shown as yellow and gray dashed lines, respectively.
