Fig. 1: Structure determination of the Drosophila TRPA1-A isoform.
From: Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel
a EM density maps of dTRPA1-A in two distinct states, with an overall resolution of 3.2 Å for state-1 (upper) and 3.0 Å for state-2 (lower). A side view is shown here with each of the four subunits colour-coded. b Cartoon representations of the dTRPA1-A structures in two states. Three views are shown here with each subunit colour-coded. c Overview of the subunit structure of dTRPA1-A in state-1. Seventeen ARs, AR0–AR17, are shown in this state with colour coding. The transmembrane domain is shown in marine blue, and the TRP helix and pre-S1 helix are coloured cyan and orange, respectively. The coiled-coil domain is shown in magenta. d Overview of the subunit structure of dTRPA1-A in state-2. The last five ARs, AR12–AR16, are visualised in this state with colour coding. The A-loop is indicated by a grey dashed circle. The three β-strands in the nexus domain are labelled β1–β3.
