Fig. 9: Schematic model of calpain regulation by the Cullin-3–RBX1–KCTD7 complex.

Shown is a comparison between WT conditions and deficiency of KCTD7 leading to calpain dysregulation and activation of a pathogenic cascade.

Shown is a comparison between WT conditions and deficiency of KCTD7 leading to calpain dysregulation and activation of a pathogenic cascade.