Fig. 6: Spermatogenic defects of the AMH-hACE2-NF/F mice after SARS-CoV-2 GFP/ΔN infection.
a Illustration and representative H&E images of testicular section of WT mice show properly arranged testicular structure, seminiferous tubules and different cell types including Sertoli cells and germ cells at various stages. b Immunofluorescence staining of SARS-CoV-2 GFP in AMH-hACE2-NF/F mouse testes. c Representative image of testis dissected from mock and SARS-CoV-2 GFP/ΔN-infected AMH-hACE2-NF/F mouse. d Average weight of testis (n = 5–10 for each group). Error bars represent mean ± SD. e The diameter of seminiferous tubules. f Sperm counts. The epididymis was dissected, sperms were rinsed out for counting the number per testicle (n = 5–10 for each group). Error bars represent mean ± SD. *P < 0.05, **P < 0.01 by t-test comparing to the controls. g Histopathological changes of testis from SARS-CoV-2 GFP/ΔN -infected AMH-hACE2-NF/F mice and control mice. h Representative H&E images of epididymis of mock and SARS-CoV-2 GFP/ΔN infected AMH-hACE2-NF/F mice.
