Fig. 2: Organization of the SIN3L complex.
From: Two assembly modes for SIN3 histone deacetylase complexes
a The scaffold of the SIN3L complex. The scaffold proteins (including Sds3, Dep1, Rxt2, and Png2) are shown in colors with the Pst1/3 Lobe shown in gray. b Structures of Pst1 and Pst3 in the two lobes. c Structural features of the Pst1 Lobe. A cartoon model of the Pst1 Lobe in an extended conformation is shown in the upper panel. The Pst1_HID stabilizes the Clr6, and the Pst1_HCR interacts with Prw1. The active site of Clr6 is exposed to the exterior space. d Structural features of the Pst3 Lobe. A cartoon model of the Pst3 Lobe in a compact state is shown in the upper panel. The Pst3_HID stabilizes the Clr6’, and the Pst3_HCR interacts with Prw1’. The Pst3_PAH3 binds to the Rxt2_α1. The active site of Clr6’ is buried inside and blocked by the Rxt2_NTD. e The EM map of the Pst3 Lobe with protein components color-coded. f The close-up views of the interactions between Clr6’ and Rxt2_NTD. g The Rxt2_NTD is further stabilized in the Pst3 Lobe.
