Table 2 Comparison of key amino acid sites in the RBD region of HPAI H5 viruses.
Key amino acid site | 133 | 136 | 137 | 138 | 153 | 158 | 160 | 183 | 186 | 190 | 192 | 193 | 196 | 216 | 221 | 225 | 226 | 227 | 228 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aviana | L | T/A | S | A | A | N | T | F | N | E | T | L | Q | R | S | G | Q | S | G |
Humana | V | S | A | V | W | S | A | H | K | D | I | R | H | E | P | D | L | N | S |
H5N8 HA1 from avian and human | |||||||||||||||||||
A/chicken/Kosovo/22-2 22VIR3124-13/2022b | L | S | A | A | W | N | A | H | N | E | T | N | K | K | S | G | Q | R | G |
A/whooper swan/Shanxi/4-1/2020H5N8 | . | . | . | . | . | . | . | . | . | . | I | . | . | . | . | . | . | . | . |
A/chicken/Egypt/Army/1201/2022 | R | . | . | . | . | . | . | . | . | . | I | . | . | . | . | . | . | . | . |
A/Astrakhan/3212/2020c | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
H5N6 HA1 from avian and human | |||||||||||||||||||
A/duck/Hunan/S40199/2021 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
A/duck/Yunnan/S4318/2021 | . | . | . | . | . | . | . | . | . | . | I | . | . | . | . | . | . | . | . |
A/duck/Zhejiang/S4854/2021 | . | . | . | . | . | . | . | . | . | . | . | D | . | . | . | . | . | . | . |
A/Hunan/09285/2021 | . | . | . | . | . | . | . | . | . | . | I | . | . | . | . | . | L | . | . |
A/Chongqing/02/2021 | . | . | . | . | . | . | . | . | . | . | I | . | . | . | . | . | X | . | . |
A/Guangdong/18SF020/2018 | . | . | . | . | . | . | . | . | . | . | . | D | . | . | . | . | . | . | . |
A/Jiangsu/1/2020 | . | . | . | . | . | . | . | . | . | . | . | K | . | . | . | . | . | G | . |
A/Chongqing/00013/2021 | . | . | . | . | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . |
A/Fujian-Sanyuan/21099/2017 | . | . | T | . | . | . | . | . | . | . | T | . | . | . | . | . | . | . | . |
H5N1 HA1 from avian and human | |||||||||||||||||||
A/duck/Guizhou/S1321/2022 | . | . | . | . | . | . | . | . | . | . | V | . | . | . | . | . | . | . | . |
A/laying hen/Moldova/68-2 22VIR638-2/2022 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
A/duck/Bangladesh/17D1821/2022 | . | . | . | . | . | D | . | . | . | . | . | R | Q | . | . | . | . | S | . |
A/chicken/Hong Kong/AP156/2008 | . | . | . | . | . | . | T | . | . | . | . | R | Q | . | . | . | . | S | . |
A/duck/Egypt/D1Br12/2007 | S | . | S | . | . | . | T | . | . | . | . | M | Q | . | . | . | . | S | . |
A/Nepal/19FL1997/2019 | . | . | . | . | . | . | . | . | . | . | . | R | Q | . | . | . | . | N | . |
A/Laos/2121/2020 | . | . | . | . | . | D | . | . | X | . | . | R | Q | R | P | . | . | S | . |
A/England/215201407/2021 | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
A/Anhui/1/2005 | S | . | S | . | . | . | T | . | . | . | . | K | Q | . | . | . | . | S | . |
A/Thailand/1(KAN-1)/2004 | . | . | S | . | . | . | T | . | . | . | . | K | Q | R | . | . | . | S | . |
A/Vietnam/1203/2004 | S | . | S | . | . | D | . | . | . | . | . | R | Q | . | . | . | . | S | . |
A/Indonesia/05/2005 | . | . | S | . | . | . | T | . | . | . | . | K | Q | R | . | . | . | S | . |
