Fig. 1: Cardiac cell subset diversity in FM mice at different time points. | Cell Discovery

Fig. 1: Cardiac cell subset diversity in FM mice at different time points.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 1

a–c Survival rate (a), ejection fraction (b), and fraction shortening (c) changes of FM mice during disease progression. d Schematic diagram of the workflow for sample processing and scRNA-seq. e Cardiac immune infiltration status among different groups. Scale bars: 100 μm. f Inflammatory score of FM mice among different groups. g quantitative PCR (qPCR) of cardiac CVB3 levels in different groups. h, i UMAP embedding of all the cardiomyocytes and immune cells colored by manually annotated cell types (h) and samples (i). j Bubble plot showing the expression levels of cell-typing genes in each cell type. The dot color represents the gene expression level, and the dot size represents the percentage of cells expressing the respective gene. k Cell component changes among different time points. l Immunohistochemical staining of cardiac autopsy samples from patients with FM. Scale bars: 50 μm.

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