Fig. 6: Blockade the self-recruiting loop of neutrophils at the early stage decreases cardiac immune infiltration and improves cardiac function. | Cell Discovery

Fig. 6: Blockade the self-recruiting loop of neutrophils at the early stage decreases cardiac immune infiltration and improves cardiac function.

From: Self-recruited neutrophils trigger over-activated innate immune response and phenotypic change of cardiomyocytes in fulminant viral myocarditis

Fig. 6

a Experimental layout of anti-Cxcr2 treatment. b Survival rate of FM mice during disease progression. c Body weight change of FM mice during disease progression. d Representative echocardiographic image of FM and Cxcr2 antibody-treated mice. e–h The ejection fraction (e), fraction shortening (f), cardiac output (g) and stroke volume (h) change of FM and Cxcr2 antibody-treated mice. i, j Representative images (i) and quantification (j) of cardiac inflammation in FM and Cxcr2 antibody-treated mice. Scale bars: 100 μm. k Representative Immunohistochemistry staining images of cardiac samples from FM mice at different time points. CD68 represents macrophages. Scale bars: 100 μm. l Cardiac CVB3 detection at different groups. m–o The relative expression of cytokines (m), chemokines (n), and marker genes of FCs (o) in cardiac samples of different groups.

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