Fig. 4: Structural comparison of HCAR2 in four active states. | Cell Discovery

Fig. 4: Structural comparison of HCAR2 in four active states.

From: Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

Fig. 4: Structural comparison of HCAR2 in four active states.The alternative text for this image may have been generated using AI.

a Extracellular and intracellular views of the comparison of the apo and agonist-bound HCAR2 structures. b Structural differences of the N-terminus and ECL2 in the four active state HCAR2 receptors. c–e Pairwise comparisons of the apo state versus niacin- (c), acipimox- (d), and MK-6892-bound (e) forms. The structures of HCAR2 and agonists are colored differently. Light gray, apo-HCAR2; forest green, niacin–HCAR2; deep sky blue, acipimox–HCAR2; hot pink, MK-6892–HCAR2; blue purple, N-terminal loop; sky blue, ECL2; yellow, niacin; dark orange, acipimox; cyan, MK-6892; magenta arrow, shift with respect to the apo state; dark gray dashed lines, polar interactions.

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