Fig. 2: Somatic genomic landscape and ethnicity-specific genomic mutations in prospectively sequenced Chinese breast cancers. | Cell Discovery

Fig. 2: Somatic genomic landscape and ethnicity-specific genomic mutations in prospectively sequenced Chinese breast cancers.

From: Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities

Fig. 2: Somatic genomic landscape and ethnicity-specific genomic mutations in prospectively sequenced Chinese breast cancers.

a A total of 4079 breast cancer samples with clinical data were ordered by molecular subtype and mutation profile, with clinical and molecular features annotated below. b The top thirteen somatically altered genes that were mutated in at least 4% of the cases (upper); somatic CDH1 and BRCA1/2 mutations (lower). Genes were ordered by the mutation frequencies, and the mutation counts for each gene are provided on the right side. c Hotspot mutations (frequency > 2%) in the Chinese population. d DDR pathway mutations in the FUSCC-BC cohort. e Copy number variations (CNVs) of cancer-related genes categorized by molecular subtype. f–h Comparison of somatic mutations in the HR+/HER2–, HER2+, and TNBC subtypes between the FUSCC and TCGA Caucasian cohorts. Logistic regression accounts for age and histology. *P < 0.05, **P < 0.01.

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