Fig. 5: Cryo-EM structure of PW5-5 IgG with Omicron XBB and SARS-CoV S trimer. | Cell Discovery

Fig. 5: Cryo-EM structure of PW5-5 IgG with Omicron XBB and SARS-CoV S trimer.

From: Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

Fig. 5: Cryo-EM structure of PW5-5 IgG with Omicron XBB and SARS-CoV S trimer.

a Cryo-EM structures of the XBB S in complex with the antibody PW5-5 IgG. b Structure of XBB RBD–PW5-5. The RBD is displayed in tomato. The heavy chain and light chain of PW5-5 are shown as ribbons colored in dark blue and light blue, respectively. c Close-up view of the PW5-535 epitope on XBB and SARS-CoV RBD. d Detailed interactions between the PW5-5 and XBB S RBD. e Detailed interactions between the PW5-5 and SARS-CoV S RBD. Hydrogen bonds are represented by dashed lines. Hydrophobic interactions are marked with red circles.

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