Fig. 1: EsxB promotes survival of M. tuberculosis via METTL14. | Cell Discovery

Fig. 1: EsxB promotes survival of M. tuberculosis via METTL14.

From: Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity

Fig. 1

a CFU assay in peritoneal macrophages from control (mMettl14f/f) or Mettl14 conditional knockout (mMettl14−/−) mice infected with H37Rv for 2 h and 24 h (MOI = 5). b Mouse peritoneal macrophages were infected with H37Rv, H37Rv:ΔEsxB, H37Rv(ΔEsxB+GFP), H37Rv(ΔEsxB+EsxB) for 2 h and 24 h, and then subjected to CFU assay (MOI = 5). c–e mMettl14f/f or mMettl14−/− mouse peritoneal macrophages infected with H37Rv, H37RvΔEsxB for 2, 24, 48, and 144 h, and then subjected to CFU assay (MOI = 1, 3, 5). Data in a–e reflect mean ± SEM from three independent biological replicates; two-tailed unpaired Student’s t-test (a–e) was used for statistical analysis.

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